Benadryl First made publically available by prescription in 1946, the popular antihistamine Benadryl®, an allergy and anti–itch medicine formulated for both for adults and children, is today available over–the–counter for oral or topical use. Manufactured by McNeil Consumer Healthcare, a subsidiary of Johnson & Johnson, the brand encompasses a variety of allergy relief and itchy skin relief solutions. The product line includes topical analgesic skin protection products such as specially formulated diphenhydramine–free children's soothing anti–itch gel that provides instant, cooling relief for insect bites, poison ivy, oak, sumac, sunburn and minor cuts and scrapes. Additional products include extra strength itch relief sticks created to provide fast, temporary relief of pain and itching caused by insect bites, rashes and more; the active ingredient is the antihistamine diphenhydramine. Products provide relief on contact.